Production scale

​CXF/AXF-1 crossflow unit

The Micropore CXF-1 is a high throughput device scaling up Micropore’s membrane emulsification technology, to enable the continuous manufacturing of high-quality emulsions in quantity, whilst retaining a tightly controlled particle size distribution.
The CXF/AXF system uses a precision engineered tubular membrane. The shear required for droplet formation is generated from the flow of the continuous phase through the device.

The AXF-1 is a precision-engineered, stainless steel, unit with no moving parts

• The AXF-1 is the aseptic version of the CXF-1, specifically designed for applications where high levels of hygiene are important. The AXF system features an electropolished stainless steel body with ergonomic tri-clamp connections, allowing for easy sterilisation.
• With no moving parts, Micropore’s XF systems are elegant and robust devices for continuously manufacturing high quality emulsions.
• The precision engineered membrane allows for the manufacture of near mono-dispersed droplets. ​

Compact, low energy, fully scaleable, production of mono-dispersed particles and microcapsules

Typical monodispersity achieveable

Laser engineered membranes
All Micropore equipment uses precision engineered stainless steel membranes. These membranes provide:

• Tightly controlled pore size
• No tortuous paths
• Easy to clean
• Robust
• Pore sizes ranging from 3 - 350µm

Fully scalable results
Micropore’s CXF/AXF-1 can be can be configured to meet precise operating requirements, as a scale up device using data from LDC-1 and LTS-1 trials to pilot manufacture volumes, or as a pilot device itself for high throughput manufacturing.
The graph shows how results obtained on the Micropore LDC-1 and LTS-1 can easily be upscaled to the CXF/AXF-1 for:

• Continuous production process
• Multi-tonne/ year capability
• Small footprint
• cGMP / FDA ready production.

Micropore Technologies CXF/AXF-1 key facts

• Production scale crossflow unit available in aseptic cGMP format for either manufacturing volumes or use as a development tool
• Suitable for producing mono-sized droplet sizes between 10 and 1000 microns
• Capable of continuous production up from1-200kg/hr 
• Utilises stainless steel tubular membranes suitable for either oil-in-water or water-in oil dispersions.
• Easy to set up and maintain with no moving parts
  
• Low energy - with resulting preservation of sensitive materials
• Tight control and operational flexibility
• Operational stability under different flow rates​
• Training available​

Click image to go to literature download page

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​​Working with Micropore was a very positive experience for us.
​The speed with which we progressed reflects how user-friendly we found the Micropore equipment.

​Customer, food sector

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​We have achieved significantly improved production economics. We were initially sceptical as we had had problems when we’d tried membrane emulsification in the past.  Micropore has developed a truly elegant solution

Customer, ​household products

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​​We set aside a day for trials on the Micropore AXF-1.  We were finished in less than an hour with all trials completed satisfactorily.  We were surprised at how simple Micropore’s equipment is to set up and operate

​​Customer, fragrance sector

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​​Micropore’s precision engineered products mean we don’t have problems with creaming or phase inversion any more.  We are working to convert manufacture of all our products to Micropore’s approach because of the ease of operation/cleaning and improved yields

​​Customer, personal care sector

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We approached Micropore after failing with others because we needed to replicate an in-flight problem.  Micropore delivered everything we hoped for and more.  The result was we were able to engineer a solution for major safety improvements and rapid implementation

​​Customer, aerospace sector

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